| 1300-1517 |              Italian                Renaissance. |            
                         | 1306-1394 |              Expulsions of Jews from France. |            
                         | 1328-1384 |              John Wycliffe (Christian dissident leader). |            
                         | 14th century |              Rise of the Ottoman                Muslim dynasty in Turkey. |            
                         | 1333 |              Casimir the Great takes power in Poland                and brings with him a sympathetic attitude toward                the Jews, who benfit as a result. |            
                         | 1348 |              Black Death reaches Europe and Jews are accused                of poisoning Christian wells. |            
                         | 1336-1405 |              Timurlane/Tamurlane, Turkic ruler in central Asia. |            
                         | 1360 |              King Pedro of Portugal                arrests and tortures to death Samuel                Ben Meir Abulafia. No charges were ever given                and the King confiscated Abulafia's lands and great                wealth. |            
                         | 1400 |              Damascus sacked by Timurlane. |            
                         | 1424 |              Jewish physician, Y'en Ch'eng is given the surname                "Chao" as an honor by the Emperor. This                family, which probably originated in India and Babylon,                became on of the leading Chinese Jewish families. |            
                         | 1437-1509 |              Philosopher, financier and scholar, Don Isaac                Abravanel intercedes many times on behalf of his                fellow Jews, including trying to stop Ferdinand                from expelling them. This time he was foiled by                Torquemada and he followed them into exile. His                commentaries cover the major and minor Prophets.                Consistent with his belief that the Messiah                would come in his lifetime, he also wrote three                messianic texts called Migdal Yeshu'ot (Tower of                Salvation). |            
                         | 1452-1454/55 |              Gutenberg prints Europe's first book with movable                type. |            
                         | 1447 |              Following a fire in Posen where the original charter                (written by Casimir the Great) granted the Jews                "privileges," Casimir IV renews all their                rights and makes his charter one of the most liberal                in Europe. This charter lasted less than a decade                before it was revoked. |            
                         | 1452-1515 |              Astronomer and historian, Abraham Zacuto creates                tables used by Columbus. After the explusion of                1492, Zacuto went to Portugal where he developed                the metal Astrolab used by Vasco Da Gama. In 1498                he was forced to flee or convert. He left and reached                Tunis where he wrote a history of the Jews from                creation until the sixteenth century. |            
                         | 1453 |              Fall of Constantinople (Istanbul) to Ottoman Muslims. |            
                         | 1454 |              Casimir IV of Poland revokes the Jewish charter,                at the insistence of Bishop Zbignev. The Bishop                had correctly predicted Casimir's defeat by the                Teutonic Knights backed by the Pope, and succeeded                in convincing the King that it was due to the Jews. |            
                         | 1463 |              Pope Nicholas V authorized the establishment of                the Inquisition                to investigate heresy among the Marranos. |            
                         | 1479-15 |              Isabella's severe anti-Jewish learnings influence                Ferdinand and lead to the final expulsion of the                Jews from Spain. |            
                         | 1486 |              First prayer                book published in Soncino,                Italy. |            
                         | 1488 |              The first complete edition of the Hebrew Bible                is printed in Soncino,                Italy. |            
                         | 1492 |              Christian expulsion of Muslim Moors from Spain. |            
                         | 1492 |              Columbus sets                sail. |            
                         | 1492 |              Christian                expulsion of Jews from Spain, sending over 200,000                Jews fleeing: 137,000 Jews forced to leave Sicily. |            
                         | 1494 |              Polish King Jan Olbracht's orders Jews to leave                to leave Crakow                for Kazimierz after they are blamed for a large                fire that destroyed part of the city. |            
                         | 1496 |              Manuel of Portugal expels Jews from Portugal. |            
                         | 1516 |              The closed Jewish Quarter in Venice,                Italy, is dubbed the Geto Nuovo (New Foundry). "Geto"                will later become the basis for the word "ghetto". |            
                         | 1505-1584 |              Kabbalist                and author of "Lecha Dodi" (Come My Beloved),                Solomon                ben Moses Alkabetz. |