Dr. Avram Hershko was born in 1937, in Karcag, Hungary. In 1950, Hershko and his family emigrated from Hungary to Israel. Hershko is a Distinguished Professor at the Unit of Biochemistry, the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology) in Haifa, Israel. He became a Professor at the Technion in 1980, and was an Associate Professor there from 1972 to 1980.
In 1969-72, Hershko was a postdoctoral fellow with the late Dr. Gordon Tomkins at the University of California, San Francisco. Hershko holds Ph. D. and M. D. D. degrees. He did his graduate work in 1967-69 at the Hadassah Medical School of the Hebrew University in Jerusalem, receiving a Ph. D. degree in 1969. Hershko received an M. D. degree in 1965, at the same Medical School. In 1965-67, Hershko worked as a physician in the Israel Defense Forces.
Hershko shared the 2004 Nobel Prize in Chemistry with Irwin Rose and Aaron Ciechanover for “for the discovery of ubiquitin-mediated protein degradation.” The following press release from the Royal Swedish Academy of Sciences describes Hershko's work:
Honors & Awards
Most relevant publications by Avram Hershko
Ciechanover, A., Hod, Y., and Hershko, A. (1978) A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100-1105.
Hershko, A., Ciechanover, A., Heller, H., Haas, A. L., and Rose, I. A. (1980) Proposed role of ATP in protein breakdown: conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc. Natl. Acad. Sci. USA 77, 1783-1786.
Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982) Covalent affinity purification of ubiquitin-activating enzyme. J. Biol. Chem. 257, 2537-2542.
Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206-8214.
Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619-1623.
Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
Sources: Albert and Mary Lasker Foundation, NobelPrize.org