(1947 - )
Dr. Aaron Ciechanover was born in 1947, in Haifa, Israel. Ciechanover is Professor at the Unit of Biochemistry and Director of the Rappaport Family Institute for Research in Medical Sciences at the Technion (Israel Institute of Technology) in Haifa. He became a Professor at the Technion in 1992, and was an Associate Professor there from 1987 to 1992.
Ciechanover holds Ph. D. and M. D. degrees. He studied medicine at the Hebrew University Medical School in Jerusalem, receiving an M. D. degree in 1974. In 1974-77, Ciechanover served in the Israel Defense Forces. In 1977-81, Ciechanover was a graduate student with Avram Hershko at the Technion. Ciechanover received a Ph. D. degree in 1981. In 1982-84, Ciechanover was a postdoctoral fellow at the Department of Biology, MIT, where he studied lasialoglycoprotein and transferrin receptors in the laboratory of Harvey Lodish, and also collaborated with Varsharsky and his student Finley in their studies of ts85 mouse cells.
Ciechanover's independent work began in 1986, at the Unit of Biochemistry, Technion, Israel.
Ciechanover shared the 2004 Nobel Prize in Chemistry with Irwin Rose and Avram Hershko for “for the discovery of ubiquitin-mediated protein degradation.” The following press release from the Royal Swedish Academy of Sciences describes Ciechanover's work:
Honors & Awards:
1996-present: Member, Council
of the European Molecular Biology Organization
Most relevant publications:
Ciechanover, A., Hod, Y., and Hershko, A. (1978) A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100-1105.
Hershko, A., Ciechanover, A., Heller, H., Haas, A. L., and Rose, I. A. (1980) Proposed role of ATP in protein breakdown: conjugation of proteins with multiple chains of the polypeptide of ATP - dependent proteolysis. Proc. Natl. Acad. Sci. USA 77, 1783-1786.
Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982) Covalent affinity purification of I ubiquitin-activating enzyme. J. Biol. Chem. 257, 2537-2542.
Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification, and role in protein breakdown. J. Biol. Chem. 258, 8206-8214.
Finley, D., Ciechanover, A. and Varshavsky, A. (1984) Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell 37, 43-55.
Ciechanover, A., Finley, D. and Varshavsky, A. (1984) Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell 37, 57-66.
Ferber, S. and Ciechanover, A. (1987) Role of Arginine-tRNA in Protein Degradation by the Ubiquitin Pathway. Nature 326,808-811. ,
Ciechanover, A., Ferber, S., Ganoth, D., Elias, S., Hershko, A. and Arfin, S. (1988) Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes: its involvement in modification and ubiquitin-dependent degradation of proteins bearing acidic N-termini. J. Biol. Chem. 263, 11155-11167.
Sources: Albert and Mary Lasker Foundation, NobelPrize.org