The Land under the Mamluks became a backwater province ruled from Damascus. Akko, Jaffa (Yafo) and other ports were destroyed for fear of new crusades, and maritime as well as overland commerce was interrupted. By the end of the Middle Ages, the country's urban centers were virtually in ruins, most of Jerusalem was abandoned and the small Jewish community was poverty-stricken. The period of Mamluk decline was darkened by political and economic upheavals, plagues, locust invasions and devastating earthquakes.
Source: Israeli Foreign Ministry